The Best Medicine For Anxiety Disorders SSRIs (selective serotonin reuptake inhibitors) and SNRIs, such as citalopram (Celexa), escitalopram (Lexapro), the fluoxetine (Prozac) duloxetine (Cymbalta) and venlafaxine (Effexor XR) are considered to be the first-line drug treatments for anxiety disorders. Psychotherapy and exercise are also essential for those suffering from anxiety.